Age related increase in the intra-alveolar macrophage population of non-smokers.
نویسندگان
چکیده
منابع مشابه
Intra-alveolar macrophage numbers in current smokers and non-smokers: a morphometric study of tissue sections.
BACKGROUND The alveolar macrophage is believed to be important in the defence of the lung and possibly in the pathogenesis of lung disease. Cell counts in bronchoalveolar lavage fluid have suggested that smokers have an increased number of alveolar macrophages but have not enabled the number to be related to a measure of lung structure. METHODS The number of alveolar macrophages was counted i...
متن کاملDeficiency of vitamin E in the alveolar fluid of cigarette smokers. Influence on alveolar macrophage cytotoxicity.
Cigarette smoking produces oxidant-mediated changes in the lung important to the pathogenesis of emphysema. Since vitamin E can neutralize reactive oxygen species and prevent peroxidation of unsaturated lipids, it may constitute an important component of the lung's defense against oxidant injury. To better characterize the antioxidant protective role of vitamin E, young asymptomatic smokers and...
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BACKGROUND Household air pollution in low income countries is an important cause of mortality from respiratory infection. We hypothesised that chronic smoke exposure is detrimental to alveolar macrophage function, causing failure of innate immunity. We report the relationship between macrophage function and prior smoke exposure in healthy Malawians. METHODS Healthy subjects exposed daily to c...
متن کاملHuman alveolar macrophage function: differences between smokers and nonsmokers.
Human alveolar macrophages and peripheral blood monocytes were obtained from smoking and nonsmoking normal volunteers. The macrophages and monocytes were incubated in vitro with bacterial lipopolysaccharide (LPS). The oxidative metabolic response of these cells was measured by superoxide anion production. Macrophages from smokers were suppressed in their superoxide anion response to LPS activat...
متن کاملComparison of Cotinine Salivary Levels in Hookah Smokers, Passive Smokers, and Non-Smokers
Background: At present smoking is considered a great health-related problem. Smoking cigarettes and use of tobacco are on the rise in the Middle East countries; therefore, the number of people exposed to passive cigarette smoke is increasing, too. The aim of the present study was to determine and compare salivary cotinine levels in hookah smokers, individuals exposed to passive cigarette smoke ...
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ژورنال
عنوان ژورنال: Thorax
سال: 1993
ISSN: 0040-6376
DOI: 10.1136/thx.48.6.668